Vitamin E Increases Antimicrobial Sensitivity by Inhibiting Bacterial Lipocalin Antibiotic Binding
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چکیده
منابع مشابه
Antibiotic Capture by Bacterial Lipocalins Uncovers an Extracellular Mechanism of Intrinsic Antibiotic Resistance
The potential for microbes to overcome antibiotics of different classes before they reach bacterial cells is largely unexplored. Here we show that a soluble bacterial lipocalin produced by Burkholderia cenocepacia upon exposure to sublethal antibiotic concentrations increases resistance to diverse antibiotics in vitro and in vivo These phenotypes were recapitulated by heterologous expression in...
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Seventyone blood cultures were taken from suspected cases of infective endocarditis. The positive cultures were isolated for study of their antibiotic susceptibility patterns. Gentamycin was found to be the most effective. Cloxacillin, chloramphenicol, Vibramycin, Tetracyclin, Erythromycin were next in order. The incidence of bacteria probably susceptible to high dose schedules and those demons...
متن کاملAntibiotic sensitivity testing in bacterial endocarditis.
Seventy-one blood cultures were taken from 26 suspected cases of bacterial endocarditis. Antibiotic sensitivity pattern was determined in 29 positive cultures. Gentamycin was found to be the most effective. Cloxacillin, chloramphenic.o1,vibramycin, tetracycline, erythromycin were next in order (J PMA 33 87,1983).
متن کاملNeutrophil gelatinase-associated lipocalin expresses antimicrobial activity by interfering with L-norepinephrine-mediated bacterial iron acquisition.
l-norepinephrine (NE) is a neuroendocrine catecholamine that supports bacterial growth by mobilizing iron from a primary source such as holotransferrin to increase its bioavailability for cellular uptake. Iron complexes of NE resemble those of bacterial siderophores that are scavenged by human neutrophil gelatinase-associated lipocalin (NGAL) as part of the innate immune defense. Here, we show ...
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The lack of effective and well-tolerated therapies against antibiotic-resistant bacteria is a global public health problem leading to prolonged treatment and increased mortality. To improve the efficacy of existing antibiotic compounds, we introduce a new method for strategically inducing antibiotic hypersensitivity in pathogenic bacteria. Following the systematic verification that the AcrAB-To...
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ژورنال
عنوان ژورنال: mSphere
سال: 2018
ISSN: 2379-5042
DOI: 10.1128/msphere.00564-18